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Specific guide to this web site for:
1. Medical
School
Educators
in
Statistics
2. Medical Students
3. Science media writers
4. High School & College
Statistic Teachers
Misadventures:
1. Harvard led MI study
2. JACC
study
(J. of Amer. Coll.
Cardio.)
3. NEJM
cath study
4. Amer. J. of Cardio.
review of literature
5. ALLHAT
controversy
6. Oat bran study
7. Pregnancy & Alcohol
8. Are Geminis
really
different?
9. Columbia 'Miracle' Study
Additional
Topics:
Celebrex
Limitations of Meta-Analyses
Large Randomized Clinical
Trials
Tale of Two Large
Trials
Advocate
meta-analyses
Network
meta-analyses
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"Subsequent
Developments" regarding an article in the Journal of the American
College of Cardiology
The problem of an indefensible,
major statistical error which led to unwarranted conclusions in this particular
study was brought to the attention of the Journal of American College of
Cardiology editors. A more formal
statistical review of all studies in this journal prior to publication was
suggested. Perhaps, in part for that reason, the Journal of American College of
Cardiology editors subsequently published an announcement that all articles
would henceforth be formally statistically reviewed as part of the Journal of
American College of Cardiology prepublication process.
The
Journal of American College of Cardiology editors wanted, similar to all editors of
major medical journals, to publish appropriately interpreted,
statistically valid studies that reliably add to the medical literature. The
editors made a significant stride in reducing such problems for subsequent
papers published in their journal.
The article critiqued in this web site was published by the Journal of American
College of Cardiology. The article had a basic, elementary misuse of statistics
that was so extreme that it was an embarrassment to a scientific journal.
The actual study was only 1 of over 100 articles published concerning a
condition where patients have chest pain but normal arteries of the heart.
Therefore, the literature on this topic was not significantly impacted in
a major negative fashion.
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