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Specific guide to this web site for:

 1.  Medical School
      in Statistics

 2.  Medical Students

 3.  Science media writers

 4.  High School & College
     Statistic Teachers


1. Harvard led MI study

2. JACC study 

   (J. of Amer. Coll.

3. NEJM cath study

4. Amer. J. of Cardio.
    review of literature


Oat bran study

Pregnancy & Alcohol

Are Geminis really
9. Columbia 'Miracle' Study  

Additional Topics:


Limitations of Meta-Analyses

Large Randomized Clinical Trials

Tale of Two Large

Advocate meta-analyses

Network meta-analyses





  Angioplasty vs. Medication and Adequate Aspirin dose for unstable angina
"10 years later"

Eventually, there were several studies in the scientific literature showing the benefit of angioplasty over medication for patients presenting with high risk unstable angina. The technique of angioplasty improved in subsequent trials (including the introduction of stents) and an appropriate dose of aspirin was subsequently used in subsequent studies. In addition, there are multiple medications that are now available that have similar or more potent effects than aspirin in inhibiting platelets which is crucial for a good outcome.

The trial critiqued in this web site concerned a trial comparing angioplasty (balloon dilatation of an artery of the heart) to clot dissolving medicines. The trial was unintentionally constructed in a way that inappropriately biased against the angioplasty group. (An inadequate, single low dose of aspirin was initially specified by trial protocol). Though the cumulative effects of low dose aspirin are potent, a single initial dose does not give the full effects of the platelet inhibition of aspirin. The full effects of aspirin are needed in order to avoid unnecessary heart attacks or complications with the use of angioplasty or stenting of the arteries of the heart.