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Specific guide to this web site for:

 1.  Medical School
      Educators 
      in Statistics

 2.  Medical Students

 3.  Science media writers

 4.  High School & College
     Statistic Teachers

   Misadventures:

1. Harvard led MI study

2. JACC study 
   (J. of Amer. Coll.
   Cardio.)

3. NEJM cath study

4. Amer. J. of Cardio.
    review of literature

5. ALLHAT
    controversy 

6. Oat bran study

7. Pregnancy & Alcohol

8. Are Geminis really
    different?
      
9. Columbia 'Miracle' Study  
                                                 

Additional Topics:

Celebrex

Limitations of Meta-Analyses

Large Randomized Clinical Trials

Tale of Two Large
Trials

Advocate meta-analyses

Network meta-analyses

An example of this would be if a very large clinical trial compared thrombolytic therapy (clot dissolving medication) to direct percutaneous coronary intervention (balloon dilation with possible stent placement in a heart artery) and did not treat the mechanical intervention (balloon dilation) group with any antiplatelet therapy (antiplatelet inhibits clot formation).  The outcome of the mechanical revascularization strategy (balloon dilation treatment) in this trial would be inferior to thrombolytic therapy (clot dissolving medication) because balloon dilatation outcome is dependent on having antiplatelet therapy present.

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