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Specific guide to this web site for:

 1.  Medical School
      Educators 
      in Statistics

 2.  Medical Students

 3.  Science media writers

 4.  High School & College
     Statistic Teachers

   Misadventures:

1. Harvard led MI study

2. JACC study 
   (J. of Amer. Coll.
   Cardio.)

3. NEJM cath study

4. Amer. J. of Cardio.
    review of literature

5. ALLHAT
    controversy 

6. Oat bran study

7. Pregnancy & Alcohol

8. Are Geminis really
    different?
      
9. Columbia 'Miracle' Study  
                                                 

Additional Topics:

Celebrex

Limitations of Meta-Analyses

Large Randomized Clinical Trials

Tale of Two Large
Trials

Advocate meta-analyses

Network meta-analyses

Oat Products and Lipid Lowering. A Meta-analysis. Ripsin CM, Keenan J, Van Horn L, et al. JAMA 1992; 267:3317-25.

This meta-analysis included 10 trials for analysis of oat bran.

There was found to be a statistically significant decrease in total cholesterol with oat bran in the combined trials. There was an average reduction of 5.1  mg/dL (0.13mmol/L) in cholesterol.

Larger reduction in cholesterol with oat soluble fiber was found to occur if the initial cholesterol level was higher than 229 mg/dL, particularly when the dose of oat soluble fiber was 3g or more.

The authors' conclusions were that "This analysis supports the hypothesis that incorporating oat products into the diet causes a modest reduction in blood cholesterol level."

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