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Specific guide to this web site for:
1. Medical
School
Educators
in
Statistics
2. Medical Students
3. Science media writers
4. High School & College
Statistic Teachers
Misadventures:
1. Harvard led MI study
2. JACC
study
(J. of Amer. Coll.
Cardio.)
3. NEJM
cath study
4. Amer. J. of Cardio.
review of literature
5. ALLHAT
controversy
6. Oat bran study
7. Pregnancy & Alcohol
8. Are Geminis
really
different?
9. Columbia 'Miracle' Study
Additional
Topics:
Celebrex
Limitations of Meta-Analyses
Large Randomized Clinical
Trials
Tale of Two Large
Trials
Advocate
meta-analyses
Network
meta-analyses
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Mills JL, et al.
Letter, Maternal alcohol consumption and birth weight. JAMA 1985:253:3351
"In reply-We appreciate the thoughtful comments of Dr.
Rosett, Ms. Weiner, and Dr. Roehm." ...
...
… "Dr.
Roehm1 suggests that birth weight may not be affected by consumption
of less than three drinks per day in nonsmokers.
While this may appear to be true for the crude data, it is clearly not
the case after adjustment for other risk factors.
After removing the effect of smoking by multiple regression, mean birth
weight is significantly decreased and the risk of intrauterine growth
retardation is significantly increased among women consuming less than three
drinks per day. This was reported in
tables 3 and 4 of our article.
We also discussed the possibility that alcohol and smoking can act
synergistically to reduce birth weight. As
noted, the alcohol-smoking interaction terms in our regression analysis did not
turn out to be statistically significant.
In summary, are data show an association between intrauterine growth retardation
and moderate as well as heavy drinking. This
association is present in both smoking and non-smoking women."
James Mills, MD, MS, Barry Graubard,
MA, George Rhoads, MD, MPH
Mills JL, Graubard BI, Harley EE, et
al. Maternal alcohol consumption and birth weight: How much drinking
during pregnancy is safe? JAMA 1984:252:1875-1879
1. Roehm E. Letter, Maternal alcohol
consumption and birth weight. JAMA 1985:253:3551
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