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Specific guide to this web site for:

 1.  Medical School
      Educators 
      in Statistics

 2.  Medical Students

 3.  Science media writers

 4.  High School & College
     Statistic Teachers

   Misadventures:

1. Harvard led MI study

2. JACC study 
   (J. of Amer. Coll.
   Cardio.)

3. NEJM cath study

4. Amer. J. of Cardio.
    review of literature

5. ALLHAT
    controversy 

6. Oat bran study

7. Pregnancy & Alcohol

8. Are Geminis really
    different?
      
9. Columbia 'Miracle' Study  
                                                 

Additional Topics:

Celebrex

Limitations of Meta-Analyses

Large Randomized Clinical Trials

Tale of Two Large
Trials

Advocate meta-analyses

Network meta-analyses

Effect on p Values when the difference in outcome events
remains constant as the number of background events increases
for a constant sample size     

                               Group  A         Group  B                                                                                                          

Number of                1,000                1,000
Participants                                                                                                                                                                

                             Number of        Number of            p value     (using Fisher’s exact test-
                                Events             Events                                  two-tailed test)   

                                       0                  25                      p< 0.0001                               

                                      25                 50                      p= 0.0044          

                                      50                 75                      p= 0.0263                

                                     100               125                     p= 0.0893            

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Effect on p Values when the number of events in Group A
increases by 5 events and in Group B decreases by 5 events

                               Group  A         Group  B                                                                                                          

Number of                1,000                1,000
Participants                                                                                                                                                                

                             Number of        Number of            p value     (using Fisher’s exact test-
                                Events             Events                                 two-tailed test)   

                                       5                  20                      p= 0.0039  

                                      30                 45                      p= 0.0988             

                                      55                 70                      p= 0.1957          

                                     105               120                     p= 0.3218      

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